God is signified by a cup, which he gives wicked men to drink, and which is an inebriating one to them, Psa 75:8 , and here it signifies the cup of the wine of the fierceness of God's wrath, which shall be given to mystical Babylon, to antichrist and his followers, Rev 14:10 , and I will bring down their strength to the earth; their strong kingdoms, fortified cities, and mighty men, their wealth and riches, of which they boasted, and in which they trusted; see Isa 26:5 . The eighteenth chapter of the Revelation is a commentary on these words. (s) "excandescentia mea", Junius & Tremellius; "aestu meo", Cocceius; so Gataker.